Chromosome 13q13–q14 locus overlaps mood and psychotic disorders: the relevance for redefining phenotype

Redefining affective disorders: relevance for drug development.

The evaluation of new drug entities with specific modes of action may be hampered by rigid diagnostic classification systems and patient selection processes that do not focus on the anticipated symptomatic, behavioral, and functional outcomes to be achieved. Patients enrolled in central nervous system (CNS) clinical trials may present with a heterogeneous group of symptoms representing several ...

Diagnosing and managing psychotic and mood disorders.

DSM-5 and psychotic and mood disorders.

The criteria for the major psychotic disorders and mood disorders are largely unchanged in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), with a few important exceptions: a new assessment tool for the psychotic disorders based on dimensional assessment, a new scheme of specifiers for the mood disorders, the addition of three new depressive disorders, and recog...

First- and Third-Person Perspectives in Psychotic Disorders and Mood Disorders with Psychotic Features

Lack of insight, very frequent in schizophrenia, can be considered a deficit in Theory of Mind (ToM) performances, and is also found in other psychiatric disorders. In this study, we used the first- to third-person shift to examine subjects with psychotic and psychotic mood disorders. 92 patients were evaluated with SANS and SAPS scales and asked to talk about their delusions. They were asked t...

Chromosome Duplication (14q) and The Genotype Phenotype Correlation